Orexin reveals how a small brain peptide controls wakefulness, explains narcolepsy, and inspires new treatments—and a search for the genome’s hidden proteins.
Whole-genome testing uncovered hidden cancer predisposition in children with leukemia, changing treatment and surveillance in a nationwide Swedish study.
A test of 511 AI-designed antibodies shows AI can improve promising drug candidates, but lab experiments remain essential for discovering safe, developable antibodies.
A one-time infusion of sugar-tagged bone marrow cells cut fragility fractures 94% in an osteoporosis trial, pointing toward a potential bone-regeneration treatment.
FDA-approved daraxonrasib targets RAS in metastatic pancreatic cancer, doubling median survival versus chemotherapy and delivering a long-awaited treatment advance.
Engineered regulatory T cells that recognize birch pollen reduced allergic airway inflammation in mice, hinting at a future cell therapy for severe allergies.
A two-antibody click-chemistry strategy improves targeted chemotherapy delivery to resistant HER2- and EGFR-positive tumors, boosting tumor control in mice.
Two undisclosed deaths in Chinese gene-editing trials renew concerns about trial oversight, safety reporting, and transparency as gene therapy advances worldwide.
Large reviews show that one to three cups of brewed coffee a day are linked with lower risks of liver disease, heart disease, stroke and Type 2 diabetes in most adults.
