Jon Hamilton

The FDA says esketamine, an antidepressant derived from the anesthetic and party drug ketamine, can now be prescribed on its own. It was approved in 2019 to treat severe depression.

In zebrafish, ketamine causes changes a brain circuit involved in "giving up." That may help explain how the drug helps people with depression.

Some weapons used by the U.S. military are so powerful they can pose a threat to the people who fire them. Today, we meet two Marines, William Wilcox and Michael Lozano, who spent years firing missiles and rockets, then developed the same rare brain condition: arteriovenous malformation, or AVM. The condition sends high pressure blood from a tangle of abnormal blood vessels directly into fragile veins, which can leak or burst. Most AVMs are caused by genetic changes that affect the growth of blood vessels, so the connection between weapon blasts and AVM isn't always immediately clear. But NPR's brain correspondent Jon Hamilton reports that recent research suggests that blast waves can alter genes in the brain — and that the evidence is even stronger for less extreme blood vessel changes.Have questions or story ideas? Let us know by emailing shortwave@npr.org!Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.

Some weapons used by the U.S. military are so powerful they can pose a threat to the people who fire them. Today, we meet two Marines, William Wilcox and Michael Lozano, who spent years firing missiles and rockets, then developed the same rare brain condition: arteriovenous malformation, or AVM. The condition sends high pressure blood from a tangle of abnormal blood vessels directly into fragile veins, which can leak or burst. Most AVMs are caused by genetic changes that affect the growth of blood vessels, so the connection between weapon blasts and AVM isn't always immediately clear. But NPR's brain correspondent Jon Hamilton reports that recent research suggests that blast waves can alter genes in the brain — and that the evidence is even stronger for less extreme blood vessel changes.Have questions or story ideas? Let us know by emailing shortwave@npr.org!Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.

Scientists have identified two types of brain cells in the abdomen that appear to control different aspects of digestion.

The Vertebrate Genomes Project: It's an ambitious effort by an international group of scientists to create a "Genome Ark" by sequencing the genomes of about 70,000 animal species. The hope is that through all of this gene sequencing, scientists will be able to answer some basic but important questions like: What makes a bird, well, a bird? What makes a mammal a mammal? Plus, with so many species on the verge of extinction, can scientists record their genetic information before they go extinct – or better yet, maybe help save the population from going extinct? Guest host Jon Hamilton, one of our favorite science correspondents, talks to Erich Jarvis, the chair of this project, to learn what this ark of animal genomes could mean for our future – and why a platypus qualified for early boarding. Want to hear more animal stories? Let us know at shortwave@npr.org — we read every email.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/s

The incoming Trump administration is likely to crack down on the H-1B visas used by tech companies and research institutions to hire top talent from other countries.

A study of cells from 84 brains finds that Alzheimer's has two distinct phases, and that one type of neuron is especially vulnerable.

Green eggs and ham? Even toddlers know when an event appears to be impossible, not just improbable.

Green eggs and ham? Even toddlers know when an event appears to be impossible, not just improbable.