Pediatric patients with large-vessel occlusion stroke are six times more likely
to have significant disability if they do not undergo mechanical thrombectomy, a
retrospective study suggests.
Registry data suggest that among clots rich in red blood cells, those with low
platelet content are associated with less disability and lower mortality after
mechanical thrombectomy.
The approval was based on a phase 3 trial showing daridorexant was associated
with improved sleep onset, sleep maintenance, and daytime functioning in adults
with insomnia.
Risk for subsequent stroke does not differ significantly for outpatient care of
transient ischemic attack or minor stroke vs inpatient care, a new meta-analysis
suggests.
Although dopamine agonists and dopamine reuptake inhibitors (DRIs) may be
effective in treating Parkinson’s disease and motor fluctuations not controlled
with levodopa, not all DRIs are equal.
The association between air pollution and white matter hyperintensity volume is
stronger among individuals who engage in vigorous physical activity for 30 or
more minutes per week, new research shows.
Diabetes is associated with a higher risk for incident Parkinson’s disease and
with worse motor symptoms, more rapid disease progression, new research
suggests.
Rasagiline 1 mg/d does not affect free-water accumulation in the posterior
substantia nigra, a marker of disease progression, a new randomized trial
suggests.
Methylphenidate is associated with a significantly greater reduction in apathy
in patients with Alzheimer’s disease compared with placebo -- and has a good
safety profile, a new phase 3 trial suggests.
The US Food and Drug Administration has approved atogepant, a novel calcitonin
gene-related peptide receptor antagonist for the prevention of migraine.
Short sleep duration is associated with impaired memory whereas long sleep is associated with impaired executive function, new research suggests. However, only one is linked to increased amyloid burden.
Overall number of global deaths by suicide rose by nearly 20,000 between 1990
and 2019, despite decreases in age-specific suicide rates, new research shows.
MRI measures have a weak and variable link to disability in patients with
secondary progressive multiple sclerosis, new research suggests. However, newer
measures may better reflect outcomes.
Dipyridamole shows promise for restless legs syndrome, reducing symptoms and
improving sleep. It potentially offers new treatment option, early research
suggests.
Intensive blood-pressure reduction as treatment for intracranial hemorrhage is
linked to a significant risk for death or disability in patients with impaired
kidney function.
Highly respected and beloved pediatric neurologist Verne Strudwick Caviness, Jr,
attended on the stroke and child neurology services at Massachusetts General
Hospital in Boston for five decades.
Stroke survivors with a walking speed of at least 0.8 m/sec can improve their
ability to simultaneously walk and perform a second task following training, new
research suggests.
An investigational oral treatment is more effective than placebo in providing
pain freedom and freedom from the most bothersome symptom at 2 hours, new phase
3 results suggest.
During a migraine attack, the IV monoclonal antibody eptinezumab provides
freedom from pain in as little as 1 hour after administration, new research
suggests.