Methylphenidate is associated with a significantly greater reduction in apathy
in patients with Alzheimer’s disease compared with placebo -- and has a good
safety profile, a new phase 3 trial suggests.
Rasagiline 1 mg/d does not affect free-water accumulation in the posterior
substantia nigra, a marker of disease progression, a new randomized trial
suggests.
Diabetes is associated with a higher risk for incident Parkinson’s disease and
with worse motor symptoms, more rapid disease progression, new research
suggests.
The association between air pollution and white matter hyperintensity volume is
stronger among individuals who engage in vigorous physical activity for 30 or
more minutes per week, new research shows.
Although dopamine agonists and dopamine reuptake inhibitors (DRIs) may be
effective in treating Parkinson’s disease and motor fluctuations not controlled
with levodopa, not all DRIs are equal.
Risk for subsequent stroke does not differ significantly for outpatient care of
transient ischemic attack or minor stroke vs inpatient care, a new meta-analysis
suggests.
The approval was based on a phase 3 trial showing daridorexant was associated
with improved sleep onset, sleep maintenance, and daytime functioning in adults
with insomnia.
Registry data suggest that among clots rich in red blood cells, those with low
platelet content are associated with less disability and lower mortality after
mechanical thrombectomy.
Pediatric patients with large-vessel occlusion stroke are six times more likely
to have significant disability if they do not undergo mechanical thrombectomy, a
retrospective study suggests.