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Deanna Macneil

Deanna Macneil

Author at the-scientist.com at The Scientist

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Influence score
32
Location
Canada
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  • English
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    Recent Articles

    the-scientist.com

    Making Moves Toward Cell Therapy for Diabetes - The Scientist

    ABOVE: Scientists are working towards pancreatic islet transplants for diabetes treatment. © iStock, AlexLMX Insulin administration is the current mainstay of type 1 diabetes therapy, but it requires frequent injections and monitoring to provide patients with glycemic control.1 As cell therapies gain traction in the clinic for different disease states, researchers aim to optimize this approach for future diabetes treatments.2 Scientists are looking into islet transplantation as a promising alte…
    over 2 years ago
    the-scientist.com

    Delivering Prime Editors With Virus-like Particles

    ABOVE: Virus-like particles combine advantages of viral and nonviral delivery methods for CRISPR gene editing. © iStock, DrAfter123 Much as a precious parcel cannot reach its destination without a reliable mail carrier, gene editors cannot make it to their target DNA without safe and effective delivery methods. Viral vectors and chemical approaches enable researchers to edit genomes in cell culture and in vivo with clustered regularly interspaced short palindromic repeats (CRISPR) and related…
    over 2 years ago
    the-scientist.com

    MEGA CRISPR: Engineering Better Immunotherapies with RNA Editing

    ABOVE: Researchers edit RNA to bypass genome editing limitations in CAR T cell engineering. © iStock, libre de droit Many foundational research technologies have transformed cellular therapies, moving treatments from concept to clinic. In the past decade, chimeric antigen receptors (CAR) and genome editing are two standouts that led to breakthrough CAR T cell therapies for leukemia and lymphoma.1 Scientists engineer these treatments with virus-mediated gene insertion ex vivo, which instructs T…
    over 2 years ago
    the-scientist.com

    Measuring Mutagenesis with Precision Genome Editing - The Scientist

    ABOVE: Precise genome editing tools transform how researchers investigate cancer mutations. Owen Gould When scientists first began applying CRISPR for genome editing in human cells, it opened the floodgates for studying disease genetics. In those early days of editing with CRISPR-Cas9, precision oncology researcher Francisco Sánchez-Rivera was a graduate student investigating cancer genetics in Tyler Jacks’ laboratory at the Massachusetts Institute of Technology (MIT). In his graduate work, he…
    over 2 years ago
    the-scientist.com

    Shifting Parturition Perspectives in Perinatology Research

    Nardhy Gómez-López investigates the placental immunology of preterm birth.
    over 2 years ago
    the-scientist.com

    Automating In Vivo Screens and Challenging Dogma - The Scientist

    ABOVE: C. elegans are exceptional model organisms for in vivo compound screens. A new lab on a chip device builds on the benefits of C. elegans culture techniques while overcoming conventional challenges. ©istock, HeitiPaves Caenorhabditis elegans is a tiny nematode species that makes big contributions to molecular research. These worms have simple genomes, well-delineated developmental processes, brief lifespans, and many conserved biological pathways across the animal kingdom, including human…
    over 2 years ago
    the-scientist.com

    Small Model Organisms as Versatile Research Tools

    Flies, worms, and fish with rapid development and characterized genetics help scientists uncover fundamental and universal biological processes, and shape cutting-edge research across disciplines.
    over 2 years ago
    the-scientist.com

    How Sperm Regulate Offspring Health

    A short term high fat diet before fertilization rewires sperm small RNA expression, passing predisposition to metabolic disease onto offspring.
    about 2 years ago
    the-scientist.com

    How Cells Know Where to Grow After Injury

    Fish fins and single-cell sequencing help scientists glean new insights into tissue regeneration.
    about 2 years ago
    the-scientist.com

    Carving Out a Niche for Muscle Stem Cells with 3D Culture

    Carving Out a Niche for Muscle Stem Cells with 3D Culture
    over 1 year ago
    the-scientist.com

    Detecting the Cell-Free DNA Fragmentome of Ovarian Cancer

    Researchers combined protein biomarkers, cfDNA analysis, and machine learning to open opportunities for early-stage ovarian cancer screening and diagnostics.
    about 1 year ago