Anjali A Sarkar

Spatial multiomics typically denotes the visualization of transcriptomic and proteomic data in the context of tissue architecture.

A study conducted on rat models is the first to demonstrate that stimulating the locus coeruleus of the brain, a region in the brain stem that is part of the reticular activating system, hastens hearing among cochlear implant recipients.

Accurate predictions of intelligence consider global profiles of whole-brain connectivity rather than spatially localized regional networks.

Researchers are developing off-the-shelf treatments to save joints before they wear out.

Tangential flow filtration provides gentle, fast concentration and diafiltration in biomanufacturing processes. To optimize tangential flow filtration, pressure must be monitored and regulated in the feed, retentate, and permeate streams, says Fredrik Lundström, senior product manager at Cytiva. He also advises that striking a balance between sufficient transmembrane pressure that achieves a high flux without fouling the membrane is critical. In processes that include diafiltration and buffer exchange, it is important to optimize the amount of target product to be concentrated to minimize buffer use and filtration time.

Using an integrated semiconductor device and their trademarked time domain sequencing technology, scientists at Quantum Si report a proof-of-principle study on the development of a next-generation, real-time, single-molecule protein sequencing technology. The technology provides a more comprehensive…

This is the largest mouse genetic study to date that has discovered chromosomal regions that modulate lifespan both early and late in life. The study provides resources for further investigations for those interested in specific genes that may modulate differences in lifespan as a function of sex and age.

Scientists at Mount Sinai have identified a regulatory protein called srGAP1 in breast cancer cells that serves as a molecular switch between invasive and proliferative states.

A CRISPR-based method can generate sterile but competitive males of a pest species that poses a threat to food crops in western countries.

A compact new adenine base editor allows the packaging of the entire editing machinery in a single AAV instead of two.