Erik Swain

Targeted vitamin D supplementation may reduce recurrent heart attack risk

NEW ORLEANS — In patients with preserved heart function after a heart attack, beta-blockers did not improve outcomes, according to a meta-analysis presented at the American Heart Association Scientific Sessions.The meta-analysis of individual patient data, simultaneously published in The New England Journal of Medicine, included 17,801 patients (median age, 62 years; 21% women) with recent

NEW ORLEANS — In patients with atrial fibrillation who had a drug-eluting stent implanted at least 1 year prior, oral anticoagulation alone was noninferior to oral anticoagulation plus clopidogrel, researchers found. While the ADAPT AF-DES trial was powered for noninferiority, the monotherapy strategy also achieved superiority, according to the researchers.

A bioadaptor implant adaptable to vessel physiology was linked to less target lesion failure and target vessel failure compared with a drug-eluting stent between 6 months and 2 years, researchers reported. As Healio previously reported, the drug-eluting coronary implant (DynamX bioadaptor scaffold, Elixir Medical) was noninferior to the DES (Resolute Onyx, Medtronic) for target lesion

In patients with suspected MI with no obstructed coronary arteries, a stratified treatment protocol was superior to standard of care for improvement in angina at 1 year, according to the results of the PROMISE trial presented at TCT 2025.The trial included 92 patients with suspected MI with no obstructed coronary arteries (MINOCA), defined as acute MI by the Fourth Universal Definition but no

In patients with severe aortic stenosis at low surgical risk, at 7 years, there was no difference in clinical outcomes or valve durability between transcatheter and surgical aortic valve replacement, according to new data from PARTNER 3.As Healio previously reported, PARTNER 3 was the first trial to compare TAVR with a balloon-expandable valve (Sapien 3, Edwards Lifesciences) and surgery in

A sirolimus-eluting balloon was noninferior to standard care for the treatment of both de novo coronary lesions and in-stent restenosis, researchers reported at TCT 2025.The SELUTION DeNovo trial evaluated the sirolimus-eluting balloon (Selution SLR, MedAlliance/Cordis) plus a provisional drug-eluting stent if needed compared with a drug-eluting stent alone in patients with de novo coronary

Paclitaxel-coated vs. uncoated devices did not reduce amputations in patients with chronic limb-threatening ischemia and raised risk for mortality at 5 years in patients with intermittent claudication, researchers reported. The SWEDEPAD 1 study of drug-coated devices vs. uncoated devices in patients with chronic limb-threatening ischemia (CLTI) and the SWEDEPAD 2 study of comparing the devices

Among adults with obesity who lost weight after following a low-calorie diet, weight-loss maintenance with exercise was associated with decreased atherosclerosis development, but weight-loss maintenance with liraglutide was not.For the trial, presented at the European Association for the Study of Diabetes annual meeting, researchers enrolled 195 patients with obesity but not diabetes (mean age,

In patients with acute myocardial infarction, screening for Helicobacter pylori did not reduce the incidence of upper gastrointestinal bleeding, researchers reported at the European Society of Cardiology Congress.For the open-label, cluster-randomized HELP-MI SWEDEHEART study, simultaneously published in JAMA, Robin Hofmann, MD, PhD, FESC, associate professor and senior consultant in the