The announcements come days after President Donald Trump struck deals with Novo Nordisk and Eli Lilly to make their GLP-1s easier for Americans to access.
Medicare will start covering obesity drugs for the first time, which could open access to millions of seniors and spur more private insurers to follow suit.
The highest dose of Eli Lilly's weekly injection helped patients with obesity or who are overweight lose 20.1% of their body weight on average at 48 weeks.
The clash reflects the shifting landscape for weight loss and diabetes drugs, with Novo Nordisk trailing Eli Lilly as companies like Pfizer race to break in.
The suit escalates a battle between Pfizer and Novo Nordisk over Metsera, whose obesity pipeline could yield new competitors in the weight loss drug market.